Subgroup Y: The Cellular and Molecular Basis of Invasive Metastatic Cancer
Wednesday, December 12, 8:30 am-11:05 am
Organizers: Mark A. McNiven, Mayo Clinic and Alissa M. Weaver, Vanderbilt University
This proposed workshop will focus on understanding the important and widespread process of how tumor cells actively remodel the surrounding microenvironment through a combination of migration and matrix degradation during the metastatic process. The program will feature experts in protease biology, cytoskeletal dynamics, in situ live cell imaging, mouse and other genetic model systems, and human pathology to provide a state-of-the-art update on new findings and technologies to both understand and curtail metastatic disease. We have organized this session at 3 previous ASCB meetings with outstanding participation and attendance.
8:30 a.m.-8:40 a.m. Introduction. Mark A. McNiven, Ph.D., Mayo Clinic, Rochester; MN
8:40-9:00 a.m. Action of the invadosome during metastasis. Gina L. Razidlo, Ph.D., Mayo Clinic, Rochester, MN
9:00-9:20. Extracellular vesicles in single cell and collective migration Bong Hwan Sung, Ph.D., Vanderbilt University, Nashville, TN
9:20-9:40 a.m. Cooperation is in our nature – using image guided genomics to deconstruct collective invasion Adam Marcus,
Ph.D., Emory University, Atlanta, GA
9:40-10:00 a.m. Nuclear deformability and expression of lamin A/C as predictors of metastatic potential in breast cancer cells
Jan Lammerding, Ph.D., Cornell University, Ithaca, NY
10:00-10:20 a.m. In vivo imaging of cancer invasion. Gautier Follain, Ph.D., INSERM, Strasbourg, France.
10:20-10:40 a.m. Tumor-stromal interactions in cancer invasion Danijela Vignjevic, Ph.D., Institut Curie, Paris, France
10:40-11:00 a.m. Eliminating metastatic cancer using genetically enhanced, enucleated cell-based therapies Richard Klemke, Ph.D.,
UC San Diego School of Medicine, San Diego, CA
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