Subgroup Y

Subgroup Y: The Cellular and Molecular Basis of Invasive Metastatic Cancer

Wednesday, December 12, 8:30 am-11:05 am
Room 29C

Organizers: Mark A. McNiven, Mayo Clinic and Alissa M. Weaver, Vanderbilt University

This proposed workshop will focus on understanding the important and widespread process of how tumor cells actively remodel the surrounding microenvironment through a combination of migration and matrix degradation during the metastatic process. The program will feature experts in protease biology, cytoskeletal dynamics, in situ live cell imaging, mouse and other genetic model systems, and human pathology to provide a state-of-the-art update on new findings and technologies to both understand and curtail metastatic disease. We have organized this session at 3 previous ASCB  meetings with outstanding participation and attendance.


8:30 a.m.-8:40 a.m.       Introduction. Mark A. McNiven, Ph.D., Mayo Clinic, Rochester; MN

8:40-9:00 a.m.               Action of the invadosome during metastasis. Gina L. Razidlo, Ph.D., Mayo Clinic, Rochester, MN

9:00-9:20.                       Extracellular vesicles in single cell and collective migration    Bong Hwan Sung, Ph.D., Vanderbilt University, Nashville, TN

9:20-9:40 a.m.                Cooperation is in our nature – using image guided genomics to deconstruct collective invasion Adam Marcus,

                                         Ph.D., Emory University, Atlanta, GA

9:40-10:00 a.m.              Nuclear deformability and expression of lamin A/C as predictors of metastatic potential in breast cancer cells

                                         Jan Lammerding, Ph.D., Cornell University, Ithaca, NY

10:00-10:20 a.m.             In vivo imaging of cancer invasion.  Gautier Follain, Ph.D., INSERM, Strasbourg, France.

10:20-10:40 a.m.            Tumor-stromal interactions in cancer invasion Danijela Vignjevic, Ph.D., Institut Curie, Paris, France

10:40-11:00 a.m.           Eliminating metastatic cancer using genetically enhanced, enucleated cell-based therapies Richard Klemke, Ph.D.,

UC San  Diego School of Medicine, San Diego, CA



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