Subgroup T

Subgroup T: The Midbody: From Cytokinesis to Signaling Organelle

Saturday, December 8, 1:30 pm-5:30 pm
Room: 28B

Organizers: Ahna R. Skop, University of Wisconsin-Madison; and Arnaud Echard, Institut Pasteur, Paris

Supported by: Bruker Corporation and 3i Intelligent Imaging Innovations

The relatively new field of midbody biology is attracting intense interest beyond its role in cytokinesis, as midbodies have been recently implicated in the fundamental control of cell architecture, fate, polarity, tumorigenicity, and pluripotency. And yet some of the most basic questions about midbody function remain unclear and at times controversial: How are midbodies generated during cytokinetic abscission? Do midbodies have post-mitotic functions and, if so, what are they and how are they regulated? How much variation in midbody function exists among distinct cell types? What proportion of post-mitotic midbodies are inherited intracellularly versus extracellularly? Do midbodies mediate informational transfer via an intracellular mechanism, an extracellular mechanism, neither, or both? What roles do midbody protein play in promoting cancer cell fate and pluripotency? It is necessary that models of midbody function must become more detailed, mechanistically speaking, to distinguish among these options. In this session, we will highlight the current research on the midbody in hopes to uncover many of these questions.


1:30 pm          Introduction: what is the midbody and why should you care? Ahna Skop, University of Wisconsin-Madison

1:45 pm          From the contractile ring to the midbody ring: a maturation process. Gilles Hickson, Université de Montréal

2:10 pm          The midbody remnant proteome or Flemmingsome reveals new proteins required for cytokinetic abscission and post-abscission events. Arnaud Echard, Institut Pasteur – CNRS, Paris, France

2:35 pm          Characterization of the midbody interactome reveals roles for PP1 phosphatases in late cytokinesis. Paolo D’Avino, University of Cambridge, UK

3:00 pm          The last chance saloon: The midbody-associated C. elegans LEM-3 nuclease mends multiple DNA intermediates just before cells divide. Anton Gartner, University of Dundee

3:25 pm          The role of post-mitotic midbodies in regulating cell proliferation and differentiation. Rytis Prekeris, University of Colorado, Anschutz Medical Campus

3:45 pm          Break

4:00 pm          Midbody transcriptome and function. Ahna Skop, University of Wisconsin-Madison

4:25 pm          Midbody function in morphogenesis. Christian Pohl, Goethe University Medical School

4:50 pm          Midbody function in epithelia architecture and polarity. Maja Köhn University of Freiburg, Germany

5:10 pm          Midbody formation and abscission in the developing brain. Noelle Dwyer, University of Virginia



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