Subgroup P: Neuronal Cytoskeleton: A Complex Interplay of Cytoarchitecture and Dynamics
Saturday, December 8, 1:30 pm-5:30 pm
Organizers: Kassandra Ori-McKenney, University of California, Davis; and Le Ma, Thomas Jefferson University
The architecture of the neuronal cytoskeleton powers the development and plasticity of a functional nervous system. This is accomplished through cytoskeletal-generated forces that power morphological changes in neurons, including neuronal migration, axon outgrowth, dendritic arborization and synaptogenesis. In addition, the neuronal cytoskeleton provides tracks for intracellular membrane and organelle transport and delivery, which can be regulated by cytoskeletal-associated proteins. Advanced molecular, genetic, and imaging techniques allow for molecular interrogation and analysis of cytoskeletal architecture and dynamics as well as intracellular trafficking in the neuron with high spatial and temporal resolution. This session will highlight novel findings and mechanistic insights into this exciting area of neuronal cell biology, and how these programs may go awry in neurodevelopmental and neurodegenerative disease.
1:30 pm Introduction. Kassandra Ori-McKenney, University of California, Davis; and Le Ma, Thomas Jefferson University
1:35 pm New insights into organization and dynamics of axonal actin. Subhojit Roy, University of Wisconsin.
1:55 pm Patterning of the axonal microtubule cytoskeleton. Shaul Yogev, Yale University.
2:15 pm Coordinating membrane and actin cytoskeleton remodeling at the synapse. Avital Rodal, Brandeis University
2:35 pm Role of microtubule acetylation and aTAT1 in shaping neuronal development. Jill Wildonger, University of Wisconsin
2:55 pm Cytoskeletal reorganization in response to stroke and other acute neuronal injuries. Shelley Halpain, University of California, San Diego
3:15 pm Doing more work with less F-actin during chemotropic growth responses: new perspectives on the molecular clutch hypothesis. Paul Forscher, Yale University
3:35 pm Break
3:50 pm Doublecortin defines a zone of microtubule nucleation and regrowth in growth cones. Gary Brouhard, McGill University
4:10 pm MAP7 regulates microtubule stability and organelle transport during axon branch development. Stephen Tymanskyj, Thomas Jefferson University
4:30 pm Lattice gating by microtubule-associated proteins differentially directs neuronal motor transport. Kassandra Ori-McKenney, University of California, Davis
4:50 pm Multiple families of motors act independently to drive the axonal transport of vesicles to the synapse. Sandra Encalada, The Scripps Research Institute
5:10 pm Novel roles for cytoplasmic dynein adaptor proteins (RDDs). Richard Vallee, Columbia University
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