Subgroup M: Cilia and Cell Signaling in Development and Tissue Regeneration
Saturday, December 8, 1:30 pm-5:30 pm
Organizers: Peter Jackson, Stanford University; and Jeremy Reiter, University of California, San Francisco
Primary and motile cilia provide critical sensory, neuroendocrine, and metabolic control in specific tissues. Studies of the cell biology of cilia, from model systems and human ciliopathies, has led to considerable insight into ciliary function, demonstrating the importance of cilia both in early development and also in controlling degeneration of tissue in pediatric and adult settings. This regenerative role is exemplified by signaling in the Sonic Hedgehog pathway, but less well understood defects lead to liver/kidney fibrosis, airway epithelia, skin, mesenchymal tissue, brain degeneration and cancer. Here we present speakers with new understanding of signaling mechanisms and structures, the elucidation of cilia signaling pathways, and animal models reflecting the importance of cilia in stem cells, tissue regeneration, and tissue pathogenesis.
1:30 pm Introduction, New Signaling Mechanisms in Cilia. Peter Jackson, Stanford University
1:50 pm Specification of cilia subtypes required for developmental signaling. Chris Kintner, Salk Institute
2:10 pm Feel the beat – multi-ciliated cell formation in the airway epithelium. Aron Jaffe, Novartis
2:30 pm The role of cilia in melanoma. Lukas Sommer, University of Zurich
2:50 pm Ciliary signaling in development and disease. Saikat Mukhopadhyay, University of Texas Southwestern
3:10 pm Loss of primary cilia drives Hedgehog to Ras pathway switching in resistant basal cell carcinoma. Francois Kuonen, Stanford University
3:25 pm Omega-3 fatty acid activation of ciliary FFAR4 receptors on perivascular preadipocyte stimulates adipogenesis. Keren Hilgendorf, Stanford University
3:40 pm Break.
3:55 pm Ciliary subdomains and signaling. Jeremy Reiter, University of California, San Francisco
4:10 pm Structure and function of the BBSome. Maxence Nachury, University of California, San Francisco
4:30 pm Cilia Assembly and Maintenance in Chlamydomonas. Karl Lechtreck, University of Georgia
4:50 pm Cilia maintain the synaptic architecture of excitatory cortical neurons. Piali Sengupta, Brandeis University
5:10 pm Ciliary extracellular vesicles: from biogenesis to bioactivity. Maureen Barr, Rutgers University
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