Subgroup H

Subgroup H: Systems and Synthetic Biology of Decoding Complex Cellular Rhythms

Saturday, December 8, 8:30 am-12:30 pm
Room: 33C

Organizer: Qiong Yang, University of Michigan, Ann Arbor

 Cell-autonomous oscillators, from sub-second action potentials to 24-hour circadian clocks, are fundamental and prevalent throughout living systems, exhibiting complicated oscillations, waves, and patterns. Despite their diversity and complexity, technology development in systems and synthetic biology triggers enormous interest and enables characterization of this universal phenomenon. In this session, a group of theorists and experimentalists will meet and discuss important topics on cellular rhythms from various perspectives crossing disciplines, e.g., principles shared among oscillators, synthetic clocks of minimal design and desired functions, tools for reconstituting more complicated dynamics and sub-cellular organization, and emerging spatiotemporal patterns from coupled oscillators. This subgroup, by bringing together biologists, physicists, and engineers with shared interests who rarely meet each other, will provide an opportunity to forge a new network of potential collaborators.


8:30 am          Introduction. Qiong Yang, University of Michigan, Ann Arbor

8:35 am          From molecules to development: how clocks function and coordinate. Qiong Yang, University of Michigan, Ann Arbor

8:55 am          Trigger waves in cell signaling. James Ferrell, Stanford University

9:15 am         Regulation of microtubule dynamics by Dachsous Lilianna Solnica-Krezel, Washington University in St. Louis

9:35 am          Cell cycle in early embryo development and the onset of zygotic genome activation. Matt Good, University of Pennsylvania

9:55 am        Engineering DNA programmed dynamical systems using a cell-free expression toolbox. Vincent Noireaux, University of Minnesota

10:15 am      Break

10:35 am        Oscillatory hormonal control of mammalian cell differentiation. Mary Teruel, Stanford University

10:55 am        Functional roles of inorganic ions in the cell. Gürol M. Süel, University of California, San Diego

11:15 am        Scaling of oscillation-based pattern. Sean Megason, Harvard Medical School

11:35 am        From single-cell oscillations to aggregates: Identifying the key control parameters driving collective signaling in Dictyostelium. Allyson Sgro, Boston University

11:55 pm        Signaling oscillations during embryonic patterning. Alexander Aulehla, EMBL Heidelberg

12:15pm  Wrap-Up and general questions


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