Subgroup F

Subgroup F: Mechanisms of DNA Repair in Maintenance of Genome Integrity

Saturday, December 8, 8:30 am-12:30 pm
Room: 29 C

Organizers: Ryan Jensen, Yale University School of Medicine; and Eli Rothenberg, New York University School of Medicine

The efficient maintenance of genome integrity and stability is vital for normal cellular functions and for prevention of diseases such as cancer. This session features research presentations from leaders in the field focusing on the intersection between DNA repair and DNA replication, genome stability, chromatin remodeling, cellular signaling, control of cell cycle checkpoints and cell death, and their implications for cancer etiology and treatment. Speakers will represent a diverse spectrum of approaches including: live cell imaging, biochemically reconstituted systems using purified proteins, super resolution microscopy to study nuclear dynamics of DNA repair complexes, replication stress and repair of DNA DSBs at stalled or collapsed replication forks, chromatin structure, and new technologies for studying DNA repair at the cellular and single molecule level.

Presentations:

8:30 am                      Opening and Intro. Ryan Jensen, Yale University, and Eli Rothenberg, New York University

8:35 am                      Fork Dynamics Determine Therapy Response in Hereditary Breast Cancer. Sharon Cantor, University of Massachusetts Medical School

8:55 am                      Maintaining the Integrity of the Genome within Chromatin. Kyle Miller, University of Texas at Austin

9:15 am                      Break Induced Replication: An unusual type of DNA synthesis promoting genomic instability. Anna Malkova, University of Iowa

9:35 am                      Illuminating the molecular functions of BRCA2. Ryan Jensen, Yale University School of Medicine

9:55 am                      Repair of DNA Nicks: Implications for Cancer, Applications to Gene Therapy. Nancy Maizels, University of Washington

10:15 am                    Break

10:25 am                    Understanding how error-prone DNA polymerases regulate the replication stress response. Tony Huang, NYU School of Medicine

10:45 am                    DNA Damage Response at the Crossroads of Repair and Apoptosis. Faye Rogers, Yale University School of Medicine

11:05 am-                  Etiology of Chromosomal Rearrangements. Jeremy Stark, City of Hope

11:25 am                    Active or not – activity dependent mobility during DNA damage responses. Shan Zha, Columbia University

11:45 am                   Targeting the ATR Checkpoint in Cancer Therapy. Lee Zhou, Harvard Medical School

12:05 pm-                  Visualizing the cellular dynamics and organization of DNA repair proteins. Eli Rothenberg, NYU School of Medicine

12:25 pm                    Concluding remarks.

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