Subgroup A

Subgroup A: 5th Biannual Frontiers in Cytokinesis

Saturday, December 8, 8:30 am-12:30 pm
Room: 33B

Organizers: Julie C. Canman, Columbia University; Ulrike Eggert, King’s College London; Amy Shaub Maddox, University of North Carolina, Chapel Hill; Douglas Robinson, Johns Hopkins School of Medicine; Dimitrios Vavylonis, Lehigh University; and Jian-Qiu Wu, Ohio State University

Cytokinesis is a spectacular cell shape change process that requires coordination of complex cellular machinery over many scales of space and time. Chemical and mechanical signaling pathways integrate the mitotic spindle with the cell cortex to position the division plane and promote assembly of a contractile actomyosin network, leading to remodeling of the plasma membrane and cortex. In a multicellular setting, cytokinesis also integrates cell-cell and cell-substrate communication. This geometrically simplified cell shape change serves as a paradigm for numerous other shape change events, including those that take place during cell migration and tissue morphogenesis. In this meeting, we bring together a group of investigators who use systematic genetic and chemical methods, biophysical techniques, high resolution imaging, diverse model systems, and mathematical modeling.

Presentations:

8:30 am          Introduction, Organizers

8:35 am          Control of cytokinesis by Plk1 in C. elegans, Sebastian Gomez-Cavazos, Oegema Lab, Ludwig Institute for Cancer Research

8:50 am          Spindle to cortex communication in frog egg, Christine Field, Harvard University

9:10 am          Actions at microtubule plus ends in the phragmoplast for cytokinesis, Bo Liu, University of California, Davis

9:30 am          Assembly and structure of the fission yeast cytokinetic ring, Kathy Gould, Vanderbilt University

9:50 am          A theory to predict the contraction rate of random cytoskeleton network, François Nedelec, EMBL

10:10 am        Work and dissipation in the cell cytoskeleton, Michael Murrell, Yale University

10:30 am        Break

10:45 am        The role of membrane shape in modulating cytokinetic furrow ingression, Jian Liu, National Institute of Heart, Lung, and Blood

11:05 am        Flagella set the stage for myosin-independent cytokinesis in Giardia, Alex Paredez, University of Washington, Seattle

11:25 am        Cleavage furrow formation without F-actin in Chlamydomonas, Masayuki Onishi, Pringle Lab, Stanford University

11:40 am        Actin oxidoreduction as a novel component of the NoCut/abscission checkpoint, Jian Bai, Echard Lab, Institut Pasteur

11:55 am        The role of calcium in Rho-dependent remodeling of epithelial tight junctions, Sara Varadarajan, Miller Lab, University of Michigan

12:10 pm        Asymmetric division, stem cell size heterogeneities and cell fate, Agathe Chaigne, Paluch Lab, MRC Laboratory for Molecular Cell Biology, University College London, UK

12:25 pm        Final remarks, Organizers

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