Subgroup R

Subgroup R: The Mechanics and Membrane Dynamics of the Nuclear Envelope

Saturday, December 8, 1:30 pm-5:30 pm
Room: 33B

Organizers: Christian Schlieker, Yale University; and Shirin Bahmanyar, Yale University

 It has become clear that the textbook definition of the nuclear envelope as a stable structure is no longer accurate. Nuclear envelope dynamics, which includes membrane fusion, rupture and repair, and budding, allows for nuclear pore complex insertion, constricted cell migration, and viral proliferation. Defects in nuclear envelope dynamics are associated with heterogeneous diseases including muscular dystrophy, movement disorders, aging, and cancer. By bringing together researchers from diverse fields that intersect in nuclear envelope biology, we will explore the mechanics and dynamics of the nuclear envelope and how mis-regulation of these processes contributes to disease. The insight gained will provide a more comprehensive view of nuclear envelope function that extends well beyond its long-assumed role as a static barrier between the nucleoplasm and cytoplasm.

 Presentations:

1:30 pm          Opening Remarks. Christian Schlieker, Yale University, and Shirin Bahmanyar, Yale University

1:35 pm          Crosstalk between chromatin and nuclear mechanics. Megan King, Yale School of Medicine

1:55 pm          Nuclear envelope rupture, DNA damage, and DNA damage response activation as drivers of lamin-associated muscular dystrophy. Jan Lammerding, Cornell University

2:15 pm          The great nuclear escape: mechanism of membrane budding during the nuclear egress of herpesviruses. Katya Heldwein, Tufts University

2:35 pm          New insight into nuclear pore complex assembly. Guillaume Holzer (Antonin Lab), Aachen University

2:55 pm          Torsin ATPases and nuclear envelope dynamics. Christian Schlieker, Yale University

3:15 pm          The ER-resident AAA+ ATPase TorsinA and its unusual oligomerization. Thomas Schwartz, Massachusetts Institute of Technology

3:35 pm          Break

3:50 pm          The nuclear envelope surveillance machinery is segregated by and directly monitors the nuclear transport system. Patrick Lusk, Yale School of Medicine

4:10 pm          Coordinating dynamic events of nuclear assembly. Katie Ullman, University of Utah

4:30 pm          Coordinating ER membrane biogenesis with nuclear envelope dynamics. Shirin Bahmanyar, Yale University

4:50 pm          Lipid metabolism of the inner nuclear membrane. Alwin Kohler, University of Vienna

5:10 pm          Concluding remarks

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