Minisymposium 8

Neural Development and Neurodegeneration

Monday, December 10
4:30-7:05 pm
Room 31B
Co-Chairs: Aaron DiAntonio, Washington University in St. Louis; and Andrea Brand, University of Cambridge, UK

4:30 pm       Introduction

*4:35 pm   M79    Uncovering the Hidden Cell Biology of the Human Brain.  S.P. Pasca1; 1Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA

4:50 pm   M80    Time to wake up: regulation of neural stem cell quiescence and reactivation.  A.H. Brand1; 1The Gurdon Institute, University of Cambridge, Cambridge, United Kingdom

5:05 pm   M81    Kinetochore Proteins Have a Post-Mitotic Function in Drosophila Neurodevelopment.  G. Zhao1, A. Oztan1, R.S. O’Neill2, N.M. Rusan2, T. Schwarz1; 1Neurobiology, Children’s Hospital, Boston, Boston, MA, 2Cell Biology and Physiology Center, National Heart, Lung, and Blood Institute, Bethesda, MD

5:20 pm   M82    Shortening heparan sulfate chains decreases parenchymal plaques and prolongs survival in prion-infected mice.  P. Aguilar-Calvo1, A. Sevillano1, J. Bapat1, K. Soldau1, D.R. Sandoval2, H.C. Altmeppen3, L. Linsenmeier3, D. Pizzo1, S.D. Edland4, M. Glatzel3, P.R. Nilsson5, J.D. Esko2, C. Sigurdson1,6,7; 1Pathology, University of California San Diego, San Diego, CA, 2Cellular and Molecular Medicine, University of California San Diego, San Diego, CA, 3Institute of Neuropathology, University Medical Center Hamburg-Eppendorf , Hamburg, Germany, 4Departments of Family Medicine & Public Health and Neurosciences, University of California San Diego, San Diego, CA, 5Physics, Chemistry, and Biology, Linköping University, San Diego, CA, 6Pathology, Immunology, and Microbiology, University of California Davis, Davis, CA, 7Medicine, University of California San Diego, San Diego, CA

5:35 pm   M83    Dual leucine zipper kinase is required for mechanical pain and microgliosis resulting from nerve injury.  J.J. Wlaschin1, J.M. Gluski1, E.K. Nguyen2, H. Silberberg1, J.H. Thompson2, A.T. Chesler2, C. Le Pichon1; 1NICHD, National Institutes of Health, Bethesda, MD, 2NCCIH, National Institutes of Health, Bethesda, MD

5:50 pm   M84    Axon Degeneration: Molecular Mechanism and Therapeutic Potential.  A. DiAntonio1;
1Developmental Biology, Washington University School of Medicine, St. Louis, MO

6:05 pm   M85    Annexin A11 dysfunction disrupts docking of RNP granules to endolysosomes in FTD/ALS.  M.S. Fernandopulle1,2, Y. Liao3, S. Qamar2, P. St. George-Hyslop2, M. Ward1, J. Lippincott-Schwartz3; 1National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, 2Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom, 3HHMI Janelia Research Campus, Ashburn, VA

6:20 pm   M86    A Mitochondrial Membrane-Spanning Ternary Machinery Regulates Mitochondrial Motility and Lifespan.  L. Li1, X. Wang1; 1Neurosurgery, Stanford University, Palo Alto, CA

6:35 pm   M87    Cellular mechanisms that prevent the liquid-to-solid phase transition of aggregation-prone proteins.  S. Spannl1,2, A.A. Hyman2, H.O. Lee1,2; 1University of Toronto, Toronto, Canada, 2Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany

6:50 pm   M88    Perturbed posttranslational polyglutamylation of the neuronal microtubule cytoskeleton causes neurodegeneration in mice and humans.  M.M. Magiera1, V. Shashi2, S. Bodakuntla1, J. Ziak3, D. Klein4, S. Rudnik-Schönebor5, M. Dusl6, S. Lacomme7, P. Catarino Marques Sousa1,8, S. Leboucher1, T.J. Hausrat9, C. Bosc10, A. Andrieux10, M. Kneussel9, M. Landry7, A. Calas7, R. Martini4, M. Balastik3, J. Senderek6, C. Janke1; 1Institut Curie, Orsay, France, 2Division of Medical Genetics, Department of Pediatrics, Duke University Medical Center, Durham, NC, 3Dept. of Molecular Neurobiology, Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic, 4Department of Neurology, Developmental Neurobiology, University Hospital Würzburg, Würzburg, Germany, 5Division of Human Genetics, Medical University Innsbruck, Innsbruck, Austria, 6Friedrich Baur Institute at the Department of Neurology, Ludwig Maximilian University of Munich, Munich, Germany, 7Bordeaux Imaging Center, BIC, Université Bordeaux, Bordeaux, France, 8Children’s Hospital, Harvard Medical School, Boston, MA, 9Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg- Eppendorf, Hamburg, Germany, 10Grenoble Institut des Neurosciences, GIN, Université Grenoble Alpes, Grenoble, France

* Sergiu Pasca is the 2018 ASCB Early Career Awardee.

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