Minisymposium 7

Motors in Transport and Cytoskeleton Remodeling

Supported by Biology Open

Monday, December 10
4:30-7:05 pm
Ballroom 20BC
Co-Chairs: Julie Welburn, University of Edinburgh; and E. Michael Ostap, University of Pennsylvania School of Medicine

4:30 pm       Introduction

4:35 pm   M69    Molecular motors destroy microtubules and catalyze tubulin exchange within the lattice.  S. Triclin1, D. Inoue1, J. Gaillard1, Z.M. Htet2, M.E. DeSantis2, D. Portran3, E. Derivery4, C. Aumeier5, L. Schaedel1, K. John6, C. Leterrier7, S.L. Reck-Peterson2, L. Blanchoin1,8, M. Théry1,8; 1Cytomorpholab, Laboratoire de Phyiologie Cellulaire & Végétale, Biosciences & Biotechnology Institute of Grenoble, Univ. Grenoble-Alpes, CEA, CNRS, INRA, Grenoble, France, 2Dept. of Cellular and Molecular Medicine, and Cell and Developmental Biology Section, Division of Biological Sciences, University of California San Diego, San Diego, CA, 3CRBM, CNRS UMR 5237, Montpellier, France, 4Laboratory of Molecular Biology, MRC , Cambridge, United Kingdom, 5Department of Biochemistry, University of Geneva , Geneva, Switzerland, 6Laboratoire Interdisciplinaire de Physique, Univ. Grenoble-Alpes, CNRS, Grenoble, France, 7NeuroCyto Lab, Aix Marseille Université, CNRS, INP UMR7051, Marseille, France, 8CytoMorpho Lab, Institut Universitaire d’Hematologie, Univ. Paris Diderot, INSERM, CEA, Hôpital Saint Louis, UMRS1160 , Paris, United States

4:50 pm   M70    Mechanisms regulating microtubule length in mitosis.  T. McHugh1, A. Gluszek1, J.P. Welburn1; 1Wellcome Trust for Cell Biology, University of Edinburgh, Edinburgh, United Kingdom

5:05 pm   M71    Using silent mutations to design a chemical probe for the microtubule-severing AAA+ protein spastin.  T. Cupido1, R. Pisa1, M.E. Kelley1, T.M. Kapoor1; 1Laboratory of chemistry and cell biology, the Rockefeller University, New York, NY

5:20 pm   M72    The RanGTP Gradient Acts as a Rheostat to Promote XCTK2 Microtubule Cross-Linking and Sliding.  S.C. Ems-McClung1, S. Zhang2, S. Mahnoor3,4, L.N. Weaver2,5, C.E. Walczak1; 1Medical Sciences Program, Indiana University, Bloomington, IN, 2Biology, Indiana University, Bloomington, IN, 3International Summer Undergraduate Research Program, Indiana University, Bloomington, IN, 4Biological Sciences, Middle East Technical University, Ankara, Turkey, 5Biochemistry and Molecular Biology, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD

5:35 pm   M73    Microtubule Attachment Geometries Affect Kinesin Attachment Durations.  S. Pyrpassopoulos1, E.M. Ostap1; 1Pennsylvania Muscle Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA

5:50 pm   M74    Cargo Adaptors Regulate the Mechanical Properties of the Mammalian Dynein-Dynactin Complex.  J. Canty1, M. Elshenawy1, L. Oster1, L.S. Ferro2, A. Yildiz1,2,3; 1Biophysics, University of California Berkeley, Berkeley, CA, 2Molecular and Cell Biology, University of California Berkeley, Berkeley, CA, 3Physics, University of California Berkeley, Berkeley, CA

6:05 pm   M75    HOOK3 is a Scaffold for Opposite Polarity Motors.  A.A. Kendrick1, W.B. Redwine1, L. Pontano Vaites2, P.T. Tran1, J.W. Harper2, S.L. Reck-Peterson1,3; 1Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, 2Department of Cell Biology, Harvard Medical School, Boston, MA, 3Division of Biological Sciences, Cell and Developmental Biology Section, University of California San Diego, La Jolla, CA

6:20 pm   M76    Transport of Mbp mRNA by Dynein and Myosin Motors in Oligodendrocytes is Critical for Local Translation and Myelination.  M. Fu1, C. Lee1, B.A. Barres1; 1Neurobiology, Stanford University, Stanford, CA

6:35 pm   M77    Myosin 18A targets the Rac/Cdc42 GEF β-PIX to dendritic spines to promote spine maturation.  C.J. Alexander1, M. Barzik2, J.A. Hammer III1; 1Cell Biology and Physiology Center, National Heart, Lung, and Blood Institute, Bethesda, MD, 2Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders, Bethesda, MD

6:50 pm   M78    Agent-based modeling of myosin motor ensembles in dynamic contractile rings.  D.B. Cortes1, F.J. Nedelec2, A.S. Maddox1; 1Biology, UNC-Chapel Hill, Chapel Hill, NC, 2EMBL, Heidelberg, Germany

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