Minisymposium 6

An Organellar Perspective on Disease

Sunday, December 9
4:15-6:50 pm
Room 30C
Co-Chairs: Michael Wangler, Baylor College of Medicine; and Blanche Schwappach, University Medical Center Göttingen

4:15 pm       Introduction

4:20 pm   M51    Pathogenic TFG mutations underlying hereditary spastic paraplegia impair secretory protein trafficking and axon fasciculation.  I. Pustova1, E. McMillan1, A. Schuh1, A. Audhya1; 1Biomolecular Chemistry, University of Wisconsin-Madison, Madison, WI

4:35 pm   M52    Phenotypic analysis of a Drosophila model for Hereditary Spastic Paraplegia.  S. Xu1, M. Stern1, J.A. McNew1; 1BioSciences, Rice University, Houston, TX

4:50 pm   M53    VPS13A and VPS13C, whose loss-of-function mutations result in neuroacanthocytosis and Parkinson’s disease respectively, are lipid transport proteins differentially localized at ER contact sites.  M. Leonzino1,2,3,4,5, N. Kumar2, F.A. Horenkamp2, W.F. Hancock-Cerutti1,2,3,4,5, P. Li2, J.A. Lees2, H. Wheeler1,2,3,4,5, K.M. Reinisch*2, P. De Camilli1,2,3,4,5; 1Neuroscience, Yale University – School of Medicine, New Haven, CT, 2Cell Biology, Yale University – School of Medicine, New Haven, CT, 3Howard Hughes Medical Institute, Yale University – School of Medicine, New Haven, CT, 4Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University – School of Medicine, New Haven, CT, 5Kavli Institute for Neuroscience, Yale University – School of Medicine, New Haven, CT

5:05 pm   M54    Accessory proteins harness the unique molecular architecture of the COPI vesicle coat.  E.C. Arakel1, V.R. Ramnarayan1, B. Schwappach1; 1University Medical Center Göttingen, Göttingen, Germany

5:20 pm   M55    A genetic screen for essential genes that impact peroxisome morphology in Drosophila and identification of candidate human disease genes.  M. Wangler1, H. Graves1, E. Seto1, K. Tan1, S. Yamamoto1; 1Molecular and Human Genetics, Baylor College of Medicine, Houston, TX

5:35 pm   M56    Role of M1 Spastin in Tethering Lipid Droplets to Peroxisomes for Trafficking of Fatty Acids.  C. Chang1, A.V. Weigel1, M.S. Ioannou1, Y. Liao1, C. Blackstone2, J. Lippincott-Schwartz1; 1HHMI Janelia Research Campus, Ashburn, VA, 2NINDS, National Institute of Health, Bethesda, MD

5:50 pm   M57    Homeostatic remodeling of mammalian membranes in response to dietary lipid perturbations directs stem cell differentiation.  K.R. Levental1, E.J. Malmberg1, I. Levental1, R. Ernst2; 1Integrative Biology and Pharmacology, McGovern Medical School at The University of TX Health Science Center at Houston, Houston, TX, 2Medical Biochemistry & Molecular Biology, University of Saarland, Homburg, Germany

6:05 pm   M58    Modulation of phosphatome to promote the lysosome function/biogenesis.  S. Patel1, D. Radhakrishnan1, S. Gangi Setty1; 1Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India

6:20 pm   M59    Macrophage catabolism of aggregated lipoproteins using a novel extracellular compartment regulates lipid accumulation during atherosclerosis.  R.K. Singh1, A.S. Haka1, V.C. Barbosa-Lorenzi1, A. Asmal1, F.W. Lund1, Y. Xiong2, H.F. Chin1, I. Grosheva1, T. Hla2, F.R. Maxfield1; 1Biochemistry, Weill Cornell Medical College, New York, NY, 2Boston Children’s Hospital and Department of Surgery, Harvard Medical School, Boston, MA

6:35 pm   M60    Dynamin-mediated disassembly and endosomal trafficking in regulated muscle remodeling of T-tubule membranes.  A.A. Kiger1, T. Lin1, N. Fujita1, W. Huang1; 1Cell & Developmental Biology, UC San Diego, La Jolla, CA

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