Minisymposium 5

Nucleus

Sunday, December 9
4:15-6:50 pm
Ballroom 20D
Co-Chairs: Xavier Darzacq, University of California, Berkeley; and Clodagh O’Shea, Salk Institute for Biological Studies

4:15 pm       Introduction

4:20 pm   M41    FIREnano and ChromEMT: Visualizing the structural basis of gene activation and silencing in the nucleus.  J. Yin1, G. Castillon2, S. Phan2, H. Ou1, T. Deerinck2, M.H. Ellisman2, C.C. O’Shea1; 1Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA, 2NCMIR, University California San Diego, La Jolla, CA

4:35 pm   M42    Nuclear organization and Transcription regulation mechanisms studied by live cell imaging.  X. Darzacq1; 1MCB, UC Berkeley, Berkeley, CA

4:50 pm   M43    A molecular sensor reveals differences in macromolecular crowding between the cytoplasm and nucleoplasm.  G.T. Shubeita1, C. Murade1; 1Physics, New York University Abu Dhabi, Abu Dhabi, United Arab Emirates

5:05 pm   M44    Spatiotemporal Patterning of Zygotic Genome Activation in Vertebrate Embryogenesis.  H. Chen1, L.C. Einstein1, M.C. Good1,2; 1Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA, 2Bioengineering, University of Pennsylvania, Philadelphia, PA

5:20 pm   M45    Dynamics of free and chromatin-bound histone H3.2 and H3.3 yield insights into chromatin changes during early embryogenesis.  Y. Shindo1, A. Amodeo1; 1Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ

5:35 pm   M46    Cryo-ET reveals nucleosome reorganisation in condensed mitotic chromosomes in vivo.  S. Cai1, C. Chen1, Z. Tan1, Y. Huang2, J. Shi1, L. Gan1; 1Department of Biological Sciences, National University of Singapore, Singapore, Singapore, 2Department of Biological Sciences and Mechanobiology Institute, Temasek Life Sciences Laboratory, Singapore, Singapore

5:50 pm   M47    Direct Visualization of Genomic Loci Relocation to Heterochromatic Condensates in Living Cells.  H. MA1, Y. Feng1,2, Y. Zhao2, A. Naseri3, S. Zhang3, J. Zheng2, T. Pederson4; 1School of Life Science and Technology, Shanghaitech University, Shanghai, China, 2School of Pharmacy, East China University of Science and Technology, Shanghai, China, 3Department of Computer Science, University of Central Florida, Orlando, FL, 4Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA

6:05 pm   M48    Analysis of chromatin dynamics reveals insights into the role of transcription in the formation of topological domains.  J.F. Johnston1, M. Bailey2, H. Yan2, S. Mochrie2,3, M.C. King1; 1Cell Biology, Yale School of Medicine, New Haven, CT, 2Physics, Yale University, New Haven, CT, 3Applied Physics, Yale University, New Haven, CT

6:20 pm   M49    Mechanotransduction regulates cell nuclear shape and function through heterochromatin content and nuclear rigidity.  A.D. Stephens1, P.Z. Liu1, V. Kandula1, H. Chen2, L.M. Almassalha3, V. Backman3, T. O’Halloran2, S.A. Adam4, R.D. Goldman4, E.J. Banigan5, J.F. Marko1,6; 1Department of Molecular Biosciences, Northwestern University, Evanston, IL, 2Department of Chemistry, Northwestern University, Evanston, IL, 3Department of Biomedical Engineering, Northwestern University, Evanston, IL, 4Department of Cell and Molecular Biology, Northwestern University Feinberg School of Medicine, Chicago, IL, 5Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Boston, MA, 6Department of Physics and Astronomy, Northwestern University, Evanston, IL

6:35 pm   M50    Visualizing spatiotemporal mRNA dynamics at subcellular resolution with a bright fluorogenic RNA.  T. Ariyoshi1, Y. Okada1; 1Lab for Cell Polarity Regulation, RIKEN BDR, Suita, Osaka, Japan

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