Minisymposium 3

Cellular Stress Responses

Sunday, December 9
4:15-6:50 pm
Room 28C
Co-Chairs: Rosa Puertollano, National Heart, Lung, and Blood Institute, NIH; and Andrew Dillin, University of California, Berkeley

4:15 pm       Introduction

4:20 pm   M21    Glia regulate ER stress resistance and longevity.  A.E. Frakes^1,2,3, M. Metcalf^1,2,3, S. Tronnes^1,2,3, H. Gildea^1,2,3, A. Dillin^1,2,3; ¹Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, ²Howard Hughes Medical Institute, Berkeley, CA, ³The Glenn Center for Aging Research , Berkeley, CA

4:35 pm   M22    The Unfolded Protein Response (UPR) Activator ATF6 Responds to Proteotoxic and Lipotoxic Stress by Distinct Mechanisms.  A.B. Tam¹, L.S. Robert², V. Chandra¹, I.G. Rivera¹, D.K. Nomura², D.J. Forbs¹, M. Niwa¹; ¹Biological Sciences, University of California, San Diego, La Jolla, CA, ²Chemistry, Molecular and Cell Biology and Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA

4:50 pm   M23    Cerebellar ataxia SCAR20 disease-associated protein Snx14 regulates lipid metabolism at ER-lipid droplet contact sites.  S. Datta¹, L. Liu¹, W.M. Henne¹; ¹Cell Biology, UT Southwestern Medical Center, Dallas, TX

5:05 pm   M24    Protein phosphatase 2A stimulates activation of TFEB and TFE3 transcription factors in response to oxidative stress.  J.A. Martina¹, R. Puertollano¹; ¹CBPC, NHLBI, National Institutes of Health, Bethesda, MD

5:20 pm   M25    Degradation of Blos1 mRNA by the unfolded protein response repositions lysosomes and protects cells from stress.  D. Bae¹, K.A. Moore¹, J. Mella¹, S. Hayashi¹, J. Hollien¹; ¹Biology, University of Utah, Salt Lake City, UT

5:35 pm   M26    Nutrient-dependent mitochondrial hyperfusion requires the modified outer membrane carrier MTCH2.  K. Labbé¹, E.A. Engelhart², Z. Minic³, J. Cazet¹, C. Juliano¹, M. Babu³, S. Hoppins², J. Nunnari¹; ¹Department of Molecular and Cellular Biology, University of California Davis, Davis, CA, ²Department of Biochemistry, University of Washington, Seattle, WA, ³Department of Biochemistry, University of Regina, Regina, SK

5:50 pm   M27    A Tyrosine Switch on NEDD4-2 E3 Ligase Transmits GPCR Inflammatory Signaling.  N.J. Grimsey^1,2, R.V. Narala¹, C.C. Rada¹, S. Metha¹, B.S. Stephens^1,3, I. Kufareva^1,3, J.J. Lapek¹, D. Gonzalez¹, T.M. Handel^1,3, J. Zhang¹, J. Trejo¹; ¹Pharmacology, University of California, San Diego, La Jolla, CA, ²Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, Athens, GA, ³Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences, La Jolla, CA

6:05 pm   M28    Ribosome assembly stress elicits an adaptive proteostatic response.  B.W. Tye^1,2, N. Commins³, M. Springer³, D. Pincus⁴, S. Churchman¹; ¹Genetics, Harvard Medical School, Boston, MA, ²Program in Chemical Biology, Harvard University, Cambridge, MA, ³Systems Biology, Harvard Medical School, Boston, MA, ⁴Whitehead Institute, Cambridge, MA

6:20 pm   M29    USP21 and OTUD3 antagonize regulatory ribosomal ubiquitylation and ribosome-associated quality control.  D.M. Garshott¹, M. Leonard¹, E. Sundaramoorthy¹, E.J. Bennett¹; ¹Cell and Developmental Biology, University of California-San Diego, La Jolla, CA

6:35 pm   M30    Reconstitution of CAT tail elongation, ubiquitination, and nascent chain release from failed ribosomes by the RQC.  C.J. Howard¹; ¹Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA

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