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Minisymposium 3

Cellular Stress Responses

Sunday, December 9
4:15-6:50 pm
Room 28C
Co-Chairs: Rosa Puertollano, National Heart, Lung, and Blood Institute, NIH; and Andrew Dillin, University of California, Berkeley

4:15 pm       Introduction

4:20 pm   M21    Glia regulate ER stress resistance and longevity.  A.E. Frakes1,2,3, M. Metcalf1,2,3, S. Tronnes1,2,3, H. Gildea1,2,3, A. Dillin1,2,3; 1Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, 2Howard Hughes Medical Institute, Berkeley, CA, 3The Glenn Center for Aging Research , Berkeley, CA

4:35 pm   M22    The Unfolded Protein Response (UPR) Activator ATF6 Responds to Proteotoxic and Lipotoxic Stress by Distinct Mechanisms.  A.B. Tam1, L.S. Robert2, V. Chandra1, I.G. Rivera1, D.K. Nomura2, D.J. Forbs1, M. Niwa1; 1Biological Sciences, University of California, San Diego, La Jolla, CA, 2Chemistry, Molecular and Cell Biology and Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA

4:50 pm   M23    Cerebellar ataxia SCAR20 disease-associated protein Snx14 regulates lipid metabolism at ER-lipid droplet contact sites.  S. Datta1, L. Liu1, W.M. Henne1; 1Cell Biology, UT Southwestern Medical Center, Dallas, TX

5:05 pm   M24    Protein phosphatase 2A stimulates activation of TFEB and TFE3 transcription factors in response to oxidative stress.  J.A. Martina1, R. Puertollano1; 1CBPC, NHLBI, National Institutes of Health, Bethesda, MD

5:20 pm   M25    Degradation of Blos1 mRNA by the unfolded protein response repositions lysosomes and protects cells from stress.  D. Bae1, K.A. Moore1, J. Mella1, S. Hayashi1, J. Hollien1; 1Biology, University of Utah, Salt Lake City, UT

5:35 pm   M26    Nutrient-dependent mitochondrial hyperfusion requires the modified outer membrane carrier MTCH2.  K. Labbé1, E.A. Engelhart2, Z. Minic3, J. Cazet1, C. Juliano1, M. Babu3, S. Hoppins2, J. Nunnari1; 1Department of Molecular and Cellular Biology, University of California Davis, Davis, CA, 2Department of Biochemistry, University of Washington, Seattle, WA, 3Department of Biochemistry, University of Regina, Regina, SK

5:50 pm   M27    A Tyrosine Switch on NEDD4-2 E3 Ligase Transmits GPCR Inflammatory Signaling.  N.J. Grimsey1,2, R.V. Narala1, C.C. Rada1, S. Metha1, B.S. Stephens1,3, I. Kufareva1,3, J.J. Lapek1, D. Gonzalez1, T.M. Handel1,3, J. Zhang1, J. Trejo1; 1Pharmacology, University of California, San Diego, La Jolla, CA, 2Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, Athens, GA, 3Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences, La Jolla, CA

6:05 pm   M28    Ribosome assembly stress elicits an adaptive proteostatic response.  B.W. Tye1,2, N. Commins3, M. Springer3, D. Pincus4, S. Churchman1; 1Genetics, Harvard Medical School, Boston, MA, 2Program in Chemical Biology, Harvard University, Cambridge, MA, 3Systems Biology, Harvard Medical School, Boston, MA, 4Whitehead Institute, Cambridge, MA

6:20 pm   M29    USP21 and OTUD3 antagonize regulatory ribosomal ubiquitylation and ribosome-associated quality control.  D.M. Garshott1, M. Leonard1, E. Sundaramoorthy1, E.J. Bennett1; 1Cell and Developmental Biology, University of California-San Diego, La Jolla, CA

6:35 pm   M30    Reconstitution of CAT tail elongation, ubiquitination, and nascent chain release from failed ribosomes by the RQC.  C.J. Howard1; 1Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA

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