Minisymposium 2

Cell Adhesion Motility and Mechanics

Sunday, December 9
4:15-6:50 pm
Ballroom 20BC
Co-Chairs: Elizabeth Chen, University of Texas Southwestern Medical Center; and Xavier Trepat, IBEC Barcelona

4:20 pm       Session Introduction

*4:20 pm   M11    Mechanical Tension Drives Cell Membrane Fusion.  E.H. Chen1; 1Molecular Biology, UT Southwestern Medical Center, Dallas, TX

**4:35 pm   M12    Energetic coordination of cooperative leader-follower dynamics during collective invasion of cancer cells.  J. Zhang1, F. Bordeleau1, C. Reinhart-King1,2; 1Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, 2Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY

4:50 pm   M13    Mechanical control of cell division and polyploidy.  M. Uroz1, A. Garcia-Puig2, I. Tekeli2, A. Elosegui-Artola1, P. Roca-Cusachs1, L. Albertazzi1, A. Raya2, X. Trepat1,3; 1Institute for Bioengineering of Catalonia, Barcelona, Spain, 2Center of Regenerative Medicine in Barcelona, Barcelona, Spain, 3Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain

5:05 pm   M14    Paxillin and tensin1 contribute to focal adhesion disassembly at mitosis to relieve an integrin-inactivation G2-M checkpoint.  H.R. Thiam1, A.M. Pasapera-Limon1, E.K. Degaga2, J.S. Urbach2, C.M. Waterman1; 1Cell Biology and Physiology Center, National Heart Lung and Blood Institute, National Institute of Health, Bethesda, MD, 2Department of Physics and The Institute for Soft Matter Synthesis and Metrology, Georgetown University Washington, Washington, DC

5:20 pm   M15    Local Contractions Test Rigidity of E-Cadherin Adhesions.  Y. Yang1, E. Nguyen1, R. Mege2, B. Ladoux1,2, M.P. Sheetz1,3; 1Mechanobiology Institute, National University of Singapore, Singapore, Singapore, 2Université Paris Diderot, Institut Jacques Monod, Paris, France, 3Department of Biological Sciences, Columbia University, New York, NY

5:35 pm   M16    Mechanical plasticity of the extracellular matrix regulates cancer cell migration through confining microenvironments.  K.M. Wisdom1, K. Adebowale2, J. Chang3, J.Y. Lee1, S. Nam1, R. Desai4, N.S. Rossen5, M. Rafat5, R. West6, L. Hodgson7, O. Chaudhuri1; 1Mechanical Engineering, Stanford University, Stanford, CA, 2Chemical Engineering, Stanford University, Stanford, CA, 3Bioengineering, Stanford University, Stanford, CA, 4School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, 5Department of Radiation Oncology, Stanford University, Stanford, CA, 6Department of Clinical Pathology, Stanford University, Stanford, CA, 7Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY

5:50 pm   M17    Nuclear rupture at sites of high curvature compromises retention of DNA repair factors.  I. Ivanovska1, Y. Xia1, K. Zhu1, R.A. Greenberg2, D.E. Discher1,2; 1Molecular & Cell Biophysics, University of Pennsylvania, Philadelphia, PA, 2Cancer Biology, University of Pennsylvania, University of Pennsylvania, PA

6:05 pm   M18    Quantifying the 3D cellular forces generated in phagocytosis using deformable microparticles.  D. Vorselen1,2, Y. Wang3, M.J. Footer1,2, W. Cai3, J.A. Theriot1,2; 1Biochemistry, Stanford University, Stanford, CA, 2Biology, University of Washington, Seattle, WA, 3Mechanical Engineering, Stanford University, Stanford, CA

6:20 pm   M19    Membrane-Cytoskeleton Mechanical Feedback Mediated by Myosin 1 Controls Phagocytic Efficiency.  S.R. Barger1, N.S. Reilly2, M. Shutova3, Q. Li4, P. Maiuri4, M.S. Mooseker5, R.A. Flavell6, T.M. Svitkina3, P.W. Oakes2,7, M. Krendel1, N.C. Gauthier4,8; 1Cell and Developmental Biology Department, State University of New York Upstate Medical University, Syracuse, NY, 2Department of Physics, University of Rochester, Rochester, NY, 3Department of Biology, University of Pennsylvania, Philadelphia, PA, 4FIRC Institute of Molecular Oncology, IFOM, Milan, Italy, 5Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT, 6Department of Immunobiology, Yale University, School of Medicine, New Haven, CT, 7Department of Biology, University of Rochester, Rochester, NY, 8Mechanobiology Institute, National University of Singapore, Singapore, Singapore

6:35 pm   M20    Mechanoregulated actin network organization and function in mammalian clathrin-mediated endocytosis.  C. Kaplan1, S.J. Kenny2, J. Schöneberg 1, S. Son3, A. Diz-Muñoz4, D.A. Fletcher3, K. Xu2, D.G. Drubin1; 1Department of Molecular and Cell Biology, University of California, Berkeley, CA, 2Department of Chemistry, University of California, Berkeley, CA, 3Department of Bioengineering, University of California, Berkeley, CA, 4Cell Biology and Biophysics Unit, European Molecular Biology Laboratory, Heidelberg, Germany

* Elizabeth Chen is the 2018 WICB Mid-Career Awardee for Excellence in Science Research.

** Jian Zhang is the 2018 Molecular Biology of the Cell Paper of the Year Awardee.

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