Minisymposium 19

Biological Insights from Organoid Models of Health and Disease

Wednesday, December 12
8:30-11:05 am
Room 33B
Co-Chairs: Dirk Hockemeyer, University of California, Berkeley; and Aron Jaffe, Novartis Institutes for Biomedical Research

8:30 am       Introduction

8:35 am   M189    Pioneer transcription factor promiscuity requires co-factors to ensure cell fate specificity.  M. Mall¹, Q. Lee², M. Wernig²; ¹Hector Institute for Translational Brain Research, German Cancer Research Center, Heidelberg, Germany, ²Institute for Stem Cell Biology and Regenerative, Stanford University, Stanford, CA

8:50 am   M190    Genetically-engineered human cortical spheroid models of Tuberous Sclerosis.  J. Blair¹, D. Hockemeyer¹, H. Bateup^1,2; ¹Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, ²Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA

9:05 am   M191    3D culture in brain-mimetic matrices demonstrates that glioblastoma tumors acquire chemotherapy resistance through matrix-mediated SRC activation.  W. Xiao¹, S. Wang², R. Zhang¹, A. Sohrabi¹, Q. Yu¹, S. Liu³, A. Ehsanipour¹, J. Liang¹, D.A. Nathanson^4,5, S.K. Seidlits^1,5,6; ¹Bioengineering, University of California Los Angeles, Los Angeles, CA, ²Microbiology, Immunology and Molecular Genetics, University of California Los Angeles, Los Angeles, CA, ³Undergraduate Interdepartmental Program for Neuroscience, University of California Los Angeles, Los Angeles, CA, ⁴Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, CA, ⁵Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, CA, ⁶Brain Research Institute, University of California Los Angeles, Los Angeles, CA

9:20 am   M192    Modeling rare cancers using patient-derived tumor organoids.  M. Mapua¹, J. Yanagawa², S. Dry³, S. Nelson³, A. Singh¹, N. Bernthal⁴, F.C. Eilber⁵, S. Memarzadeh⁶, R. Damoiseaux⁷, N. Federman⁸, A. Soragni¹; ¹Division of Hematology-Oncology, Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA, ²Division of Thoracic Surgery, Department of Surgery, David Geffen School of Medicine, UCLA, Los Angeles, CA, ³Department of Pathology, Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA, ⁴Division of Orthopaedic Oncology, Department of Orthopaedics, David Geffen School of Medicine, UCLA, Los Angeles, CA, ⁵Division of Surgical Oncology, Department of Surgery, David Geffen School of Medicine, UCLA, Los Angeles, CA, ⁶Department of OB-GYN, David Geffen School of Medicine, UCLA, Los Angeles, CA, ⁷Department of Molecular and Medicinal Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, CA, ⁸Department of Pediatrics and Department of Orthopaedics, David Geffen School of Medicine, UCLA, Los Angeles, CA

9:35 am   M193    Investigating the specification of the CFTR-rich pulmonary ionocyte.  L.W. Plasschaert¹, R. Zilionis², R. Choo-Wing¹, V. Savova², J. Knehr³, G. Roma³, H. Yang⁴, Y. Wang⁴, M. Hild⁴, A.M. Klein², A.B. Jaffe¹; ¹Respiratory Diseases, Novartis Institutes for BioMedical Research, Cambridge, MA, ²Systems Biology, Harvard Medical School, Boston, MA, ³Chemical Biology and Therapeutics, Novartis Institutes for BioMedical Research, Basel, Switzerland, ⁴Chemical Biology and Therapeutics, Novartis Institutes for BioMedical Research, Cambridge, MA

9:50 am   M194    Cellular aspect ratio and cell division mechanics intermix cell lineages in the intestinal epithelium.  K.L. McKinley¹, N. Stuurman¹, L.A. Royer², C. Schartner³, D. Castillo-Azofeifa⁴, M. Delling³, O.D. Klein⁴, R.D. Vale¹; ¹Cellular and Molecular Pharmacology, UCSF/HHMI, San Francisco, CA, ²Chan Zuckerberg Biohub, San Francisco, CA, ³Physiology, UCSF, San Francisco, CA, ⁴Orofacial Sciences, UCSF, San Francisco, CA

10:05 am   M195    Modeling cellular dynamics underlying H. pylori VacA-host cell interaction using gastric organoids.  X. Liu¹, X. Liu^1,2, P.Y. Yao¹, S. Muthusamy^1,2, X. Song^1,2, W. Wang^2,3, C. Henry¹, X. Ding³, D. Wang^2,3, X. Yao²; ¹Physiology, Morehouse School of Medicine, Atlanta, United States, ²Organelle Dynamics, Keck Center for Cellular Dynamics, Hefei, China, ³Medicine, Beijing University of Chinese Medicine, Beijing, China

10:20 am   M196    Organoids reveal roles for multicellular interactions that establish aging-related epigenetic and transcriptional states in human mammary epithelia.  M. Miyano^1,2, R. Sayaman^1,2, M. Todhunter^1,2, M. Stampfer³, M.A. LaBarge^1,2,3; ¹Population Sciences, Beckman Research Institute at City of Hope, Duarte, CA, ²Center for Cancer and Aging, City of Hope, Duarte, CA, ³Biological Systems and Engineering, Lawrence Berkeley National Laboratory, Duarte, CA

10:35 am   M197    Tissue Mechanics Guide Reprograming Of Deep Ectoderm Through Mesenchymal-To-Epithelial Transition On The Surface Of Embryonic Aggregates.  H. Kim^1,2, T. Jackson¹, C. Sruckenholz¹, L. Davidson¹; ¹Bioengineering, University of Pittsburgh, Pittsburgh, PA, ²Institute for Basic Science, Daejeon, South Korea

10:50 am   M198    Cell cycle control of blood progenitors regulates their fate and differentiation state.  L.M. Goins¹, B.C. Mondal¹, J.R. Girard¹, U. Banerjee^1,2,3; ¹Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA, ²Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA, ³Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA

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