Minisymposium 19

Biological Insights from Organoid Models of Health and Disease

Wednesday, December 12
8:30-11:05 am
Room 33B
Co-Chairs: Dirk Hockemeyer, University of California, Berkeley; and Aron Jaffe, Novartis Institutes for Biomedical Research

8:30 am       Introduction

8:35 am   M189    Pioneer transcription factor promiscuity requires co-factors to ensure cell fate specificity.  M. Mall1, Q. Lee2, M. Wernig2; 1Hector Institute for Translational Brain Research, German Cancer Research Center, Heidelberg, Germany, 2Institute for Stem Cell Biology and Regenerative, Stanford University, Stanford, CA

8:50 am   M190    Genetically-engineered human cortical spheroid models of Tuberous Sclerosis.  J. Blair1, D. Hockemeyer1, H. Bateup1,2; 1Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, 2Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA

9:05 am   M191    3D culture in brain-mimetic matrices demonstrates that glioblastoma tumors acquire chemotherapy resistance through matrix-mediated SRC activation.  W. Xiao1, S. Wang2, R. Zhang1, A. Sohrabi1, Q. Yu1, S. Liu3, A. Ehsanipour1, J. Liang1, D.A. Nathanson4,5, S.K. Seidlits1,5,6; 1Bioengineering, University of California Los Angeles, Los Angeles, CA, 2Microbiology, Immunology and Molecular Genetics, University of California Los Angeles, Los Angeles, CA, 3Undergraduate Interdepartmental Program for Neuroscience, University of California Los Angeles, Los Angeles, CA, 4Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, CA, 5Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, CA, 6Brain Research Institute, University of California Los Angeles, Los Angeles, CA

9:20 am   M192    Modeling rare cancers using patient-derived tumor organoids.  M. Mapua1, J. Yanagawa2, S. Dry3, S. Nelson3, A. Singh1, N. Bernthal4, F.C. Eilber5, S. Memarzadeh6, R. Damoiseaux7, N. Federman8, A. Soragni1; 1Division of Hematology-Oncology, Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA, 2Division of Thoracic Surgery, Department of Surgery, David Geffen School of Medicine, UCLA, Los Angeles, CA, 3Department of Pathology, Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA, 4Division of Orthopaedic Oncology, Department of Orthopaedics, David Geffen School of Medicine, UCLA, Los Angeles, CA, 5Division of Surgical Oncology, Department of Surgery, David Geffen School of Medicine, UCLA, Los Angeles, CA, 6Department of OB-GYN, David Geffen School of Medicine, UCLA, Los Angeles, CA, 7Department of Molecular and Medicinal Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, CA, 8Department of Pediatrics and Department of Orthopaedics, David Geffen School of Medicine, UCLA, Los Angeles, CA

9:35 am   M193    Investigating the specification of the CFTR-rich pulmonary ionocyte.  L.W. Plasschaert1, R. Zilionis2, R. Choo-Wing1, V. Savova2, J. Knehr3, G. Roma3, H. Yang4, Y. Wang4, M. Hild4, A.M. Klein2, A.B. Jaffe1; 1Respiratory Diseases, Novartis Institutes for BioMedical Research, Cambridge, MA, 2Systems Biology, Harvard Medical School, Boston, MA, 3Chemical Biology and Therapeutics, Novartis Institutes for BioMedical Research, Basel, Switzerland, 4Chemical Biology and Therapeutics, Novartis Institutes for BioMedical Research, Cambridge, MA

9:50 am   M194    Cellular aspect ratio and cell division mechanics intermix cell lineages in the intestinal epithelium.  K.L. McKinley1, N. Stuurman1, L.A. Royer2, C. Schartner3, D. Castillo-Azofeifa4, M. Delling3, O.D. Klein4, R.D. Vale1; 1Cellular and Molecular Pharmacology, UCSF/HHMI, San Francisco, CA, 2Chan Zuckerberg Biohub, San Francisco, CA, 3Physiology, UCSF, San Francisco, CA, 4Orofacial Sciences, UCSF, San Francisco, CA

10:05 am   M195    Modeling cellular dynamics underlying H. pylori VacA-host cell interaction using gastric organoids.  X. Liu1, X. Liu1,2, P.Y. Yao1, S. Muthusamy1,2, X. Song1,2, W. Wang2,3, C. Henry1, X. Ding3, D. Wang2,3, X. Yao2; 1Physiology, Morehouse School of Medicine, Atlanta, United States, 2Organelle Dynamics, Keck Center for Cellular Dynamics, Hefei, China, 3Medicine, Beijing University of Chinese Medicine, Beijing, China

10:20 am   M196    Organoids reveal roles for multicellular interactions that establish aging-related epigenetic and transcriptional states in human mammary epithelia.  M. Miyano1,2, R. Sayaman1,2, M. Todhunter1,2, M. Stampfer3, M.A. LaBarge1,2,3; 1Population Sciences, Beckman Research Institute at City of Hope, Duarte, CA, 2Center for Cancer and Aging, City of Hope, Duarte, CA, 3Biological Systems and Engineering, Lawrence Berkeley National Laboratory, Duarte, CA

10:35 am   M197    Tissue Mechanics Guide Reprograming Of Deep Ectoderm Through Mesenchymal-To-Epithelial Transition On The Surface Of Embryonic Aggregates.  H. Kim1,2, T. Jackson1, C. Sruckenholz1, L. Davidson1; 1Bioengineering, University of Pittsburgh, Pittsburgh, PA, 2Institute for Basic Science, Daejeon, South Korea

10:50 am   M198    Cell cycle control of blood progenitors regulates their fate and differentiation state.  L.M. Goins1, B.C. Mondal1, J.R. Girard1, U. Banerjee1,2,3; 1Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA, 2Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA, 3Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA

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