Minisymposium 18

Autophagy and Protein Quality Control

Wednesday, December 12
8:30-11:05 am
Ballroom 20BC
Co-Chairs: Martin Graef, Max Planck Institute for Biology of Ageing, Cologne; and Harm Kampinga, University Medical Center Groningen, and University of Groningen, The Netherlands

8:30 am       Introduction

8:35 am   M179    Molecular chaperones, macroautophagy and protein aggregation diseases.  H. Kampinga1; 1Cell Biology, UMCG/RuG, Groningen, Netherlands

8:50 am   M180    The organization and consequence of accumulating unfolded proteins in mitochondria.  L. Ruan1,2,3, X. Zhang1,2,4, J. McNamara1,2,3, A. Chang1,2, J. Zhu1,2, C. Na5, A. Peterson3, R. Li1,2,4; 1Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD, 2Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, 3Biochemistry, Cellular and Molecular Biology (BCMB) Graduate Program, Johns Hopkins University School of Medicine, Baltimore, MD, 4Diana Helis Henry Medical Research Foundation, New Orleans, LA, 5Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD

9:05 am   M181    Gp78 regulation of mitophagy by PINK1 and USP13 deubiquitinase is mediated by its CUE domain.  Y. Mohammadzadeh1, B. Joshi1, G. Gao1, I.R. Nabi1; 1Cell and Physiological Sciences, University of British Columbia, Vancouver, BC

9:20 am   M182    The nucleus is a common quality control destination for failed mitochondrial import substrates.  V.P. Shakya1, W. Barbeau1, C. Knutson1, A.L. Hughes1; 1Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT

9:35 am   M183    Mechanism of protein quality control at the inner nuclear membrane: lessons from the SUN-protein, Mps3, in budding yeast.  B.A. Koch1, H. Yu1; 1Biology, Florida State University, Tallahassee, FL

9:50 am   M184    Parallel genome-wide CRISPR analysis identified substrate-specific modules and a role for heterotypic ubiquitin chains in ER-Associated Degradation.  D.E. Leto1, D.W. Morgens2, L. Zhang3, C.P. Walczak1, J. Elias3, M.C. Bassik2,4, R.R. Kopito1; 1Department of Biology, Stanford University, Stanford, CA, 2Department of Genetics, Stanford University, Stanford, CA, 3Department of Chemical and Systems Biology, Stanford University, Stanford, CA, 4Program in Chemistry, Engineering and Medicine for Human Health, Stanford University, Stanford, CA

10:05 am   M185    Illuminating degradation: The coordination and timing of substrate processing by the 26S proteasome.  J.A. Bard1, E. Jonsson1,2, A. Martin1,2,3; 1Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA, 2Howard Hughes Medical Institute, University of California at Berkeley, Berkeley, CA, 3 University of California at Berkeley, California Institute for Quantitative Biosciences, Berkeley, CA

10:20 am   M186    Activation of ER stress response in a premature aging disease.  S. Vidak1, T. Misteli1; 1Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD

10:35 am   M187    Characterization of LAMP1-labeled degradative and non-degradative autophagic-lysosomal organelles in the nervous system.  X. Cheng1, Y. Xie1, B. Zhou1, N. Huang1, T. Farfel-Becker1, Z. Sheng1; 1Synaptic Function Section, NINDS, National Institutes of Health, Bethesda, MD

10:50 am   M188    Proteome remodeling in human ATG conjugation system-deficient cells.  L. Pontano Vaites1, J.A. Paulo1, O. Owoyemi1, J.W. Harper1; 1Department of Cell Biology, Harvard Medical School, Boston, MA

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