Minisymposium 17

Regulation of Autophagy

Supported by Biogen
Tuesday, December 11
4:15-6:50 pm
Room 31B
Co-Chairs: Meng Wang, Baylor College of Medicine; and Hong Zhang, Institute of Biophysics, Chinese Academy of Sciences

4:15 pm       Introduction

4:20 pm   M169    Tethering the ER with the isolation membrane for autophagosome formation.  Y. Zhao1, H. Zhang1,2; 1Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA, 2National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China

4:35 pm   M170    The autophagy-related gene ATG2A encodes a lipid transfer protein.  S. Yu^1, D. Valverde^1, V. Boggavarapu2, T. Walz2, K.M. Reinisch*1, T.J. Melia*1; 1Department of Cell Biology, Yale University, New Haven, CT, 2Laboratory of Molecular Electron Microscopy, The Rockefeller University, New York, NY

4:50 pm   M171    Conserved protein machinery regulates the autophagosome lipid composition.  M. Graef1; 1MPRG Graef, Max Planck Institute for Biology of Ageing, Cologne, Germany

5:05 pm   M172    Differential proteomic analysis identifies TEX264 as a novel receptor for ER autophagy.  H. CHINO1,2, T. Hatta3, T. Natsume3, N. Mizushima1; 1Department of Biochemistry and Molecular Biology, The University of Tokyo, Tokyo, Japan, 2Department of Respiratory Medicine, The University of Tokyo, Tokyo, Japan, 3Biomedical Information Research Center, National Institute of Advanced Industrial Science and Technology, Tokyo, Japan

5:20 pm   M173    A novel Atg39-mediated nucleolar autophagy pathway in response to DNA replication stress.  A. Van Elgort1, L. Perucho Jamies1, K.B. Kaplan1; 1Molecular and Cellular Biology, University of California, Davis, Davis, CA

5:35 pm   M174    Lysosomal Signaling in Orchestrating Cellular and Organism Homeostasis.  M.C. Wang1,2; 1Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, 2Howard Hughes Medical Institute, Chevy Chase, MD

5:50 pm   M175    Distinct Spatiotemporal Control of Macro-autophagy by Acute Glucose Restriction Remodels Vacuole Liquid-ordered Membrane Domain to Regulate Cellular Lipid Metabolism and Survival during Starvation.  A.Y. Seo1, F. Sarkleti1, J. Lippincott-Schwartz1; 1Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA

6:05 pm   M176    A novel autophagic mechanism mediating cellular lipid droplet catabolism.  R.J. Schulze1, M.B. Schott1, S.G. Weller1, E.W. Krueger1, C.A. Casey2, M.A. McNiven1; 1Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, 2Internal Medicine, University of Nebraska Medical Center, Omaha, NE

6:20 pm   M177    Structural and biochemical analyses of the autophagic ATG2A-WIPI4 complex.  S. Chowdhury1, C. Otomo1, A. Leitner2, K. Ohashi1, A. Rudolf2,3, G.C. Lander1, T. Otomo1; 1Integrative Structural and Computational Biology, The Scripps Research Institute, San Diego, CA, 2Institute of Molecular Systems Biology, Eidgenössische Technische Hochschule Zürich, Zurich, Switzerland, 3Faculty of Science, University of Zurich, Zurich, Switzerland

6:35 pm   M178    Coordination of Class II PI3-kinase and Mtm PI3-phosphatase functions in autophagy.  A.A. Kiger1, J. Groulx1, S. Jean1, M. Velichkova1, P. Kadandale1, N. Fujita1, S. Cox1, S. Kumar1; 1Cell & Developmental Biology, UC San Diego, La Jolla, CA

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