Tuesday, December 11
Co-Chairs: Adam Hughes, University of Utah School of Medicine; and Marisa Otegui, University of Wisconsin-Madison
4:15 pm Introduction
4:20 pm M159 Systematic superresolution analysis of endocytosis reveals an actin nucleation nano-template that drives efficient vesicle formation. M. Mund1,2, J. Beek1, J. Deschamps1, S. Dmitrieff1, P. Hoess1, J. Monster1, A. Picco2, F.J. Nedelec1, M. Kaksonen2, J. Ries1; 1Cell Biology and Biophysics, European Molecular Biology Laboratory, Heidelberg, Germany, 2Department of Biochemistry, University of Geneva, Geneva, Switzerland
4:35 pm M160 Actin-independent endocytosis in yeast revealed through visualization of intracellular sterols with a bacterial toxin bio-sensor. M. Marek1, S.G. Martin1; 1Department of Fundamental Microbiology, University of Lausanne, Lausanne, Switzerland
4:50 pm M161 FERARI: an unusual tether involved in endocytic recycling. J.A. Solinger1, H. Rashid1, A. Spang1; 1Biozentrum, University of Basel, Basel, Switzerland
5:05 pm M162 Architecture of mammalian retromer by single particle cryo-EM. A.K. Kendall1, B. Xie1,2, C. Jung1, E. Binshtein1, S.E. Collier1, P. Xu1, R. Burcham1, T. Graham1, T. Nakagawa1, L.P. Jackson1;
1Biological Sciences, Vanderbilt University, Nashville, TN, 2Center for Structural Biology, Vanderbilt University, Nashville, TN
*5:20 pm M163 Catalytic activation of β-arrestins by GPCRs promotes independent β-arrestin trafficking and signaling. K. Eichel1, D. Jullié1, B. Barsi-Rhyne1, N. Latorraca2, M. Masureel2, J. Sibarita3, R. Dror2, M. von Zastrow1; 1Psychiatry, University of California San Francisco, San Francisco, CA, 2Molecular and Cellular Physiology, Stanford University, Stanford, CA, 3Interdisciplinary Institute for Neuroscience, Bordeaux, France
5:35 pm M164 Mechanism of miRNA sorting into extracellular vesicles. M.M. Temoche-Diaz1, M.J. Shurtleff1,2, R. Nottingham3, J. Yao3, A. Lambowitz3, R.W. Schekman2; 1Plant and Microbial Biology, University of California, Berkeley, Berkeley, CA, 2Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, 3Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX
5:50 pm M165 Mitochondrial-Derived Compartments Promote Nutrient-Dependent Remodeling of the Mitochondrial Proteome. M. Schuler1, A.M. Litwiller1, T.J. Campbell1, T. Tedeschi1, J.M. Shaw1, A.L. Hughes1; 1Biochemistry, University of Utah, Salt Lake City, UT
6:05 pm M166 The triggering of a spatially segregated ESCRT-nuclear envelope repair system leads to local nuclear membrane remodeling. D.J. Thaller1, M. Allegretti2, S. Borah1, M. Beck2, P. Lusk1; 1Cell Biology, Yale School of Medicine, New Haven, CT, 2EMBL, Heidelberg, Germany
6:20 pm M167 Lipid homeostasis is maintained by dual targeting of the mitochondrial PE biosynthesis enzyme Psd1 to the ER. J.R. Friedman1,2, M. Kannan3, A. Toulmay3, C.H. Jan4,5, W. Prinz3, J.S. Weissman4, J. Nunnari2; 1Cell Biology, UT Southwestern Medical Center, Dallas, TX, 2Molecular and Cellular Biology, University of California Davis, Davis, CA, 3NIDDK, NIH, Bethesda, MD, 4Department of Cellular and Molecular Pharmacology, UCSF, San Francisco, CA, 5Calico Life Sciences, South San Francisco, CA
6:35 pm M168 Reticulon proteins in plants: Membrane remodeling and autophagy. X. Zhang1, X. Ding1, R. Marshall2, R.D. Vierstra2, M.S. Otegui1; 1Laboratory of Cell and Molecular Biology, University of Wisconsin-Madison, Madison, WI, 2Biology, Washington University at St Louis, St Louis, MO
* Kelsie Eichel is the 2018 ASCB Merton Bernfield Awardee.
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