Minisymposium 15

Cytoskeleton, Motility, and Cell Mechanics: Tracks

Tuesday, December 11
4:15-6:50 pm
Ballroom 20BC
Co-Chairs: Brad Nolen, University of Oregon; and Radhika Subramanian, Harvard Medical School and Massachusetts General Hospital

4:15 pm       Introduction

4:20 pm   M149    Activation of Arp2/3 complex by WISH/DIP/SPIN90 (WDS) proteins, a family of nucleation promoting factors that seed branched actin network assembly.  Q. Luan1, C.J. Balzer1, A.R. Wagner1, S. Liu1, L.A. Helgeson2, B.J. Nolen1; 1Chemistry and Biochemistry, University of Oregon, Eugene , OR, 2Biochemistry, University of Washington, Seattle, WA

4:35 pm   M150    A complex containing lysine-acetylated actin and cyclase-associated protein inhibits the formin INF2.  M. A1, H.N. Higgs1; 1Biochemistry, Dartmouth College, Hanover, NH

4:50 pm   M151    Bil2, a dual (positive and negative) regulator of formin activity, controls cell compartment-specific actin cable assembly.  T.J. Rands1, B.L. Goode1; 1Biology, Brandeis University, Waltham, MA

5:05 pm   M152    Ena/VASP is fine-tuned for processive elongation on actin filaments bundled by filopodia crosslinker fascin.  A.J. Harker1, H.H. Katkar2,3,4, T.C. Bidone2,3,4, F. Aydin2,3,4, G.A. Voth2,3,4, D.A. Applewhite5, D.R. Kovar1,6; 1Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, 2Department of Chemistry, University of Chicago, Chicago, IL, 3The James Franck Institute, University of Chicago, Chicago, IL, 4Institute for Biophysical Dynamics, University of Chicago, Chicago, IL, 5Department of Biology, Reed College, Portland, OR, 6Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, IL

5:20 pm   M153    Muscle specific stress fibers give rise to sarcomeres and are mechanistically distinct from stress fibers in non-muscle cells.  A.M. Fenix1, M.R. Visetsouk2, N. Taneja1, A.C. Neininger1, R. Garde2, B. Liu3, B.R. Nixon4, A. Manalo4, J.R. Becker4, S.W. Crawley5, D. Bader4, M.J. Tyska1, Q. Liu3, J.H. Gutzman2, D.T. Burnette1; 1Cell and Developmental Biology, Vanderbilt University, Nashville, TN, 2Biological Sciences, University of Wisconsin Milwaukee, Milwaukee, WI, 3Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, 4Medicine, Vanderbilt University Medical Center, Nashville, TN, 5Biological Sciences, The University of Toledo, Toledo, OH

5:35 pm   M154    Severing enzymes amplify microtubule arrays through lattice GTP-tubulin incorporation.  A. Vemu1, E. Szczesna1, E. Zehr1, J.O. Spector1, N. Grigorieff2,3, A.M. Deaconescu 4, A. Roll-Mecak1,5; 1Cell Biology and Biophysics Unit, Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, Bethesda, MD, 2Howard Hughes Medical Institute,, Brandeis University, Waltham, MA, 3Howard Hughes Medical Institute, Janelia Farm Research Campus, Ashburn, VA, 4Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI, 5Biochemistry & Biophysics Center, National Heart, Lung and Blood Institute, Bethesda, MD

5:50 pm   M155    Human β-tubulin isotypes regulate microtubule protofilament number and stability.  S. Ti1, G.M. Alushin2, T.M. Kapoor1; 1Laboratory of Chemistry and Cell Biology, The Rockefeller University, New York, NY, 2Laboratory of Structural Biophysics and Mechanobiology, The Rockefeller University, New York, NY

6:05 pm   M156    Cryo-EM structure of the tubulin cofactors-Arl2-alpha/beta-tubulin complex reveal the molecular basis for alpha/beta-tubulin biogenesis and topology.  Z. Wang1, F. Guo1, J.K. Moore2, J. Al-Bassam1; 1Molecular Cellular Biology, University of California, Davis, Davis, CA, 2Cell and Developmental Biology, University of Colorado, Denver, Denver , CO

6:20 pm   M157    Direct induction of microtubule branching by microtubule nucleation factor SSNA1.  N. Basnet1, H. Nedozralova1, A.H. Crevenna2, S. Bodakuntla3, T. Schlichthaerle1, M. Taschner4, G. Cardone1, C. Janke3, R. Jungmann1, M.M. Magiera3, C. Biertuempfel1, N. Mizuno1; 1Department of Structural Cell Biology, Max Planck Institute of Biochemistry, Munich, Germany, 2Biomolecular Self-Organization, Instituto de Tecnologia Química e Biológica António Xavier, Lisbon, Portugal, 3Genotoxic Stress and Cancer, Institut Curie, Paris, France, 4Department of Fundamental Microbiology, University of Lausanne, Lausanne, Switzerland

6:35 pm   M158    The means to an end: How the ciliary kinesin Kif7 finds microtubule ends.  S. Jiang1, N. Mani1, E.M. Wilson-Kubalek2, P. Ku1, R.A. Milligan2, R. Subramanian1; 1Molecular Biology, Harvard Medical School and MGH, Boston, MA, 2The Scripps Research Institute, San Diego, CA

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