Minisymposium 11

Spindle Mechanics and Chromosome Segregation

Monday, December 10
4:30-7:05 pm
Ballroom 20A
Co-Chairs: Iva Tolic, Ruđer Bošković Institute (RBI), Croatia; and Daniel Gerlich, Institute of Molecular Biotechnology of the Austrian Academy Sciences (IMBA)

4:30 pm       Introduction

4:35 pm   M109    Forces, torques, and architecture of the mitotic spindle.  B. Polak1, J. Simunić1, B. Kuzmić1, M. Jagrić1, J. Martinčić1, P. Risteski1, K. Vukušić1, R. Buđa1, M. Novak2, N. Pavin2, I.M. Tolić1;
1RBI, Zagreb, Croatia, 2University of Zagreb, Zagreb, Croatia

4:50 pm   M110    Electron tomographic reconstructions of mammalian spindles provide information about interactions between kinetochore microtubules and interpolar microtubule bundles.  E.T. O’Toole1, M.K. Morphew1, J.R. McIntosh1; 1MCD Biology, University of Colorado, Boulder, CO

*5:05 pm   M111    Cell Division: Mechanical Integrity with Dynamic Parts.  C.L. Hueschen1, P. Suresh1, A.F. Long1, S. Dumont1; 1Cell & Tissue Biology, University of California, San Francisco, San Francisco, CA

5:20 pm   M112    Kinetochore-mediated multivalency of Ndc80 complex is essential to harness the power stroke of bending protofilaments at the microtubule end.  V.A. Volkov1, P.J. Huis in ’t Veld2, A. Musacchio2, M. Dogterom1; 1Bionanoscience Department, Delft University of Technology, Delft, Netherlands, 2Department of Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology, Dortmund, Germany

5:35 pm   M113    Molecular and evolutionary strategies of meiotic cheating by selfish centromeres.  T. Akera1, E. Trimm1, M.A. Lampson1; 1Department of Biology, University of Pennsylvania, Philadelphia, PA

5:50 pm   M114    Chromosome mechanics during nuclear assembly.  S. Cuylen1,2, M. Petrovic1, M. Samwer1, M.W. Schneider1, D.W. Gerlich1; 1IMBA – Institute of Molecular Biotechnology, Vienna, Austria, 2EMBL – European Molecular Biology Laboratory, Heidelberg, Germany

6:05 pm   M115    A contractile actomyosin network on the nuclear envelope remnant positions human chromosomes for mitosis.  A.J. Booth1, Z. Yue1, J.K. Eykelenboom1, G. Luxton2, H. Hochegger3, T.U. Tanaka1; 1Centre for Gene Regulation and Expression, University of Dundee, Dundee, United Kingdom, 2Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN, 3Genome Damage and Stability Centre, University of Sussex, Brighton, United Kingdom

6:20 pm   M116    Chromosome segregation fidelity in epithelia requires tissue architecture.  K.A. Knouse1, K.E. Lopez2,3,4, M. Bachofner5, A. Amon2,3,4; 1Whitehead Institute for Biomedical Research, Cambridge, MA, 2Biology, Massachusetts Institute of Technology, Cambridge, MA, 3Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 4Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA, 5Biology, Swiss Federal Institute of Technology (ETH Zurich), Zurich, Switzerland

6:35 pm   M117    Cell cycle asynchrony and DNA damage at mitotic entry contribute to the evolution of polyploid karyotypes.  R. Basto1, S. Gemble1, A. Simon1, V. Fraisier1, V.E. Marthiens1, M. Nano1; 1Cell Biology, Institut Curie, Paris, France

6:50 pm   M118    DNA-dependent innate immune signaling by cGAS controls mitotic cell death and the response to taxol.  C. Zierhut1, N. Yamaguchi2, H. Funabiki1; 1Laboratory of Chromosome and Cell Biology, The Rockefeller University, New York, NY, 2Laboratory of Systems Cancer Biology, The Rockefeller University, New York, NY

* Sophie Dumont is the 2018 WICB Junior Awardee for Excellence in Science Research.

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