Microsymposium 12

Regulation of Membrane Trafficking

Monday, December 10
11:00 am-12:00 pm
Room 29B
Moderators: Courtney Schroeder, Fred Hutchinson Cancer Research Center; and Sara Wong, University of Michigan

11:00 am   E67   Clearance of emerin, a tail-anchored inner nuclear membrane protein, by the rapid ER stress-induced export (RESET) pathway. A.L. Buchwalter1, M.W. Hetzer2; 1Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, 2Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA

11:10 am   E68    The tubular ER shaping protein Reticulon 4a enhances exocytosis independently of its effect on ER morphology.  R. Mukherjee1, Z. Zhang2, D.L. Levy1; 1Molecular Biology, University of Wyoming, Laramie, WY, 2Zoology and Physiology, University of Wyoming, Laramie, WY

11:20 am   E69    Mutant p53 activates a Dynamin-1/APPL1 endosome nexus downstream of EGFR/Akt to regulate beta-1 integrin recycling and migration.  A.M. Lakoduk1, P. Roudot1, M. Mettlen1, H.M. Grossman1, S.L. Schmid1, P. Chen1; 1Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX

11:30 am   E70    Ca2+– dependent activation of Arf5 at ER/Plasma Membrane contact sites by an IQSec1/ORP3 complex controls focal adhesion turnover and cell migration.  R.S. D’Souza1, A. Turgut1, J. Lim1, J.F. Durel1, K. Orth2, J. Zhang2, M. Sohn3, Y. Kim3, T. Balla3, J.E. Casanova1; 1Cell Biology, University of Virginia, Charlottesville, VA, 2Molecular Biology, University of Texas, Southwestern Medical Centre, Dallas, TX, 3NICHD/DIR, Bethesda, MD

11:40 am   E71    Single Grb2 recruitment dynamics are modulated by ECM mechanics.  D. Thakar1, S. Low-Nam2, F. Kai1, J.N. Lakins1, G. Ou1, S.D. Hansen2, J.T. Groves2, V.M. Weaver1,3,4; 1Department of Surgery, University of California San Francisco, San Francisco, CA, 2Department of Chemistry, University of California Berkeley, Berkeley, CA, 3Department of Anatomy, University of California San Francisco, San Francisco, CA, 4Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA

11:50 am   E72    A nutrient-induced affinity switch controls mTORC1 activation by its Rag GTPase-Ragulator lysosomal scaffold.  R.E. Lawrence1, K.F. Cho1, R. Rappold1, A.F. Thrun1, M. Tofaute1, D. Kim1, O. Moldavski1, R. Zoncu1, J.H. Hurley1; 1Molecular and Cell Biology, UC Berkeley, Berkeley, CA

Click here to return to full list of Microsymposia.