Microsymposium 9

Cell Division and Mitosis

Monday, December 10
11:00 am-12:00 pm
Room 30C
Moderator: Emily Summerbell, Emory University

11:00 am   E49    The Chromosome Passenger Complex phosphorylates SAF-A/hnRNP-U to mediate clearance of nuclear, chromatin-associated RNAs during prometaphase.  J.A. Sharp1,2, M.D. Blower1,2; 1Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, 2Department of Genetics, Harvard Medical School, Boston, MA

11:10 am   E50    SNAP-based inhibition of localized kinase activity reveals the roles of Aurora A and Polo-like kinase 1 at the centrosomes during mitosis.  P.J. Bucko1, C.K. Lombard2, A. Bhat1, F.D. Smith1, D.J. Maly2, J.D. Scott1; 1Department of Pharmacology, University of Washington, Seattle, WA, 2Department of Chemistry, University of Washington, Seattle, WA

11:20 am   E51    Non-cell autonomous spindle morphology contributes to mitotic vulnerability of embryonic neural stem cells in mammals.  V.E. Marthiens1, D. Vargas-Hurtado1, J. Brault1, D. Krndija1, T. Piolot2, L. Leconte1, C. Pennetier1, N. Da Silva1, A. Baffet1, R. Basto1; 1UMR144, Institut Curie, Paris, France, 2UMR3215, Institut Curie, Paris, France

11:30 am   E52    Mild Replication Stress increases Microtubule Stability and induces premature Centriole Disengagement in Mitosis, favoring Chromosome Segregation Errors.  T. Wilhelm1, A. Olziersky1, D. Harry1, H. Vassal1,2, P. Meraldi1; 1Cell Physiology and Metabolism, University of Geneva, Geneva, Switzerland, 22National Institute of Applied Sciences, Lyon, France

11:40 am   E53    ATP deprivation during a prolonged mitosis compromises kinetochore structure, SAC signaling and cell fate determination.  J. Oliveira1, A. Santos1, C. Ferras1; 1CID Lab, IBMC, i3S, Porto, Portugal

11:50 am   E54    The tumor suppressor SETD2 functions as a dual regulator of microtubule and kinetochore assembly during mitosis.  F.M. Mason1, S.R. Norris1, I. Park2, C.L. Walker2, R. Ohi3, W.K. Rathmell1; 1Medicine, Vanderbilt University Medical Center, Nashville, TN, 2Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, 3Cell and Developmental Biology, University of Michigan, Ann Arbor, MI

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