Microsymposium 7

Advances in Mechanisms of Cellular Stress 

Monday, December 10
11:00 am-12:00 pm
Room 30B
Moderator: Arunika Das, University of Pennsylvania

11:00 am   E37    Temperature increases cause transposon-associated DNA damage specific to spermatocytes and not oocytes.  N.A. Kurhanewicz¹, J.M. Helm¹, D.E. Libuda^1,2; Institute of Molecular Biology, University of Oregon, Eugene, OR, ²Department of Biology, University of Oregon, Eugene, OR

11:10 am   E38    Actin-mediated structural changes preserve neuron integrity in the early hours after experimental stroke.  B. Calabrese^1,2, S.L. Jones³, U. Manor⁴, T.M. Svitkina³, H.N. Higgs⁵, A.Y. Shih⁶, S. Halpain^1,2; ¹Division of Biological Sciences, UC San Diego, La Jolla, CA, ²Sanford Consortium for Regenerative Medicine, UC  San Diego, La Jolla, CA, ³Departmen of Biology, University of Pennsylvania, Philadelphia, PA, ⁴Biophotonics Core Facility, Salk Institute, La Jolla, CA, ⁵Department of Biochemistry, Dartmouth Medical School, Hanover, NH, ⁶Department of Neurosciences, Medical University of South Carolina, Charleston, SC

11:20 am   E39    The Role of Sigma-1-Receptor in Endoplasmic Reticulum Stress and Alzheimer’s Disease.  T.T. Nguyen^1,2, K.L. Ferguson², P. Chudalayandi^1,2, R. Bergeron^1,2; ¹Neuroscience, Ottawa Hospital Research Institute , Ottawa, ON, ²Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON

11:30 am   E40    Enforcing cellular stress promotes apoptotic and immunogenic responses in melanoma.  S.M. Daignault^1,2, L. Spoerri^1,2, R.J. Ju^1,2, D.S. Hill^3,4, S.J. Stehbens^1,2, R. Dolcetti^1,2, N.K. Haass^1,2,3,4;¹Diamantina Institute, University of Queensland, Brisbane, Australia, ²Translational Research Institute, Woolloongabba, Australia, ³The Centenary Institute, Newtown, Australia, ⁴Dermatological Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom

11:40 am   E41    Yeast tRNA ligase structure reveals kinetic competition between non-conventional mRNA splicing and mRNA decay.  J. Peschek^1,2, P. Walter^1,2; ¹Biochemistry and Biophysics, UC San Francisco, San Francisco, CA, ²HHMI, Chevy Chase, MD

11:50 am   E42    Cell Stress Biosensors for Rapid, Live-Cell Detection of Neurotoxic and Cardiotoxic Compounds in iPSC-Derived Neurons and Cardiomyocytes.  K.M. Harlen¹, T. Hughes^1,2, A.M. Quinn¹; ¹Montana Molecular, Bozeman, MT, ²Cell Biology and Neuroscience, Montana State University, Bozeman, MT

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