Microsymposium 3

Mechanisms of Neurodegeneration

Sunday, December 9
11:00 am-12:00 pm
Room 29B
Moderator: Ashley Rowland, University of Colorado, Boulder

11:00 am   E13    Mitochondrial Stress Disassembles Nuclear Architecture through Proteolytic Activation PKCδ and Lamin BI phosphorylation in Neuronal Cells: Implications for Pathogenesis of Parkinson’s Disease.  A.G. Kanthasamy1, A. Charli1, J. Luo1, B. Palanisamy1, E. Malovic1, H. Jin1, V. Anantharam1, A. Kanthasamy1; 1Department of Biomedical Sciences, Iowa State University, Ames, IA

11:10 am   E14    Phosphoinositide deficiency underlies enhanced neuronal excitability in NPC disease.  O. Vivas1, S.A. Tiscione1, J. Horvath1, R. Dixon1, S. Cologna2, D.S. Ory3, E.J. Dickson1; 1Department of Physiology and Membrane Biology, University of California, Davis, CA, 2Department of Chemistry, University of Illinois, Chicago, IL, 3Department of Internal Medicine, Washington University School of Medicine , St. Louis, MO

11:20 am   E15    Extracellular Tau Can Be Taken Up by Neurons And Microglia Involving M1 and M3 Receptors With Opposite Effects: Normal Tau Promotes Growth of Neurites Whereas Pathological Leads to Neurodegeneration.  V. Morozova1,2, A.D. Alonso1,2, L. Cohen1; 1Biology and Center for Developmental Neurosciences, College of Staten Island, Staten Island, NY, 2Biology, CUNY, The Graduate Center, New York, NY

11:30 am   E16    Activation of STAT3 by IL-6 confers drug resistance in Medulloblastoma.  L. Sreenivasan1,2, H. Wang3, S. Yap1,3, C. Liu1,2, P. Leclair2,3, C. Liu2,3; 1Experimental Medicine, University of British Columbia, Vancouver, BC, 2Michael Cuccione Childhood Cancer Research Program, BC Children’s Hospital Research Institute, Vancouver, BC, 3Pediatrics, University of British Columbia, Vancouver, BC

11:40 am   E17    UNC-16/JIP3 primes the axon for regeneration and supports regrowth after axotomy through regulation of DLK-1 dependent and DLK-1 independent cytoskeletal dynamics.  S.S. Kulkarni1, V. Sabharwal2, S. Sheoran1, A. Basu3, K. Matsumoto4, N. Hisamoto4, A. Ghosh Roy3, S.P. Koushika2; 1Neurobiology, NCBS-TIFR, Bangalore, India, 2Biological Sciences, DBS-TIFR, Mumbai, India, 3NBRC, Gurgaon, India, 4Nagoya University, Nagoya, Japan

11:50 am   E18    ALS-linked SOD1 Mutants Induce Enhanced Outgrowth, Branching, and Filopodia Formation in Adult Motor Neurons.  Z. Osking1, J.I. Ayers2, R. Hildebrandt3, K. Skruber1, H. Brown2, D. Ryu2, A.R. Eukovich1, T.E. Golde2, D. Borchelt2, T.A. Read1, E.A. Vitriol1; 1Anatomy and Cell Biology, University of Florida, Gainesville, FL, 2Neuroscience, University of Florida, Gainesville, FL, 3Molecular Genetics and Microbiology, University of Florida, Gainesville, FL

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