Microsymposium 11

Cytoskeleton and Disease

Monday, December 10
11:00 am-12:00 pm
Room 29C
Moderator: Scott Wilkinson, National Institutes of Health

11:00 am   E61    Dynamic recruitment of the retinal degeneration gene product CCDC66 to the centrosome/cilium complex is regulated by satellites and microtubules.  E.N. Firat-Karalar1, D. Conkar1; 1Molecular Biology and Genetics, Koc University, Istanbul, Turkey

11:10 am   E62    Intracellular Cholesterol Transport Requires StARD9, a Novel Multifunctional Kinesin that Couples LDL Uptake to Projection of Lysosomal Membrane Tubules.  F.R. Newton1, S.N. Leahy1, E.M. Gertbauer1, P.S. Vaughan1, K.T. Vaughan1; 1Biological Sciences, University of Notre Dame, Notre Dame, IN

11:20 am   E63    Identification and characterization of Vasohibins/SVBP as long-sought α-tubulin detyrosinating enzymes: importance for neuron and brain.  M. Moutin1,2, C. Aillaud1,2, C. Bosc1,2, L. peris1,2, P. Heemerick1,2, J. Deloulme1,2, J. Le Friec1,2, b. Boulan1,2, S. Syed3, Y. Couté4, M.S. Bogyo3, S. Humbert1,2, A. Andrieux1,2,5; 1Grenoble Institut des Neurosciences (GIN), Univ. Grenoble Alpes, Grenoble, France, 2Grenoble Institut des Neurosciences (GIN), Inserm, U1216, Grenoble, France, 3Department of Pathology, Stanford University School of Medicine , Stanford, CA, 4BIG-BGE, Univ. Grenoble Alpes, CEA, INSERM, Grenoble, France, 5BIG-GPC , CEA, Grenoble, United States

11:30 am   E64    The in situ structure of a pathogenic mutant of LRRK2 in Parkinson’s Disease.  R. Watanabe1, R. Buschauer 1,2, J. Böhning1, M. Audagnotto 1, D. Boassa3, S.S. Taylor4, E. Villa1; 1Molecular Biology, University of California, San Diego, La Jolla, CA, 2Biochemistry, Gene Center Munich, University of Munich, Munich, Germany, 3The National Center for Microscopy and Imaging Research, University of California, San Diego, La Jolla, CA, 4Chemistry & Biochemistry, Pharmacology, University of California, San Diego, La Jolla, CA

11:40 am   E65    UNC-45A is novel, ATP-independent, MT destabilizing protein that regulates cancer cells’ response to mitotic poisons.  A. Mooneyham1,2, Y. Lizuka1,2, Q. Yang3, C.E. Coombes3, M. McClellan3, V. Shridhar4, E. Emmings1,2, M. Shetty1,2, L. Chen5, T. Ai5, J. Meints6, M.K. Lee6, M.K. Gardner3, M. Bazzaro1,2; 1Department of Obstetrics, Gynecology and Women’s Heath, University of Minnesota, Minneapolis, MN, 2Masonic Cancer Center, University of Minnesota, Minneapolis , MN, 3Department of Genetics, Cell Biology, and Development, University of Minnesota , Minneapolis, MN, 4Department of Experimental Pathology, Mayo Clinic College of Medicine, Rochester, MN, 5Center for Drug Design, Academic Health Center, University of Minnesota, Minneapolis, MN, 6Department of Neuroscience, University of Minnesota, Minneapolis, MN

11:50 am   E66    Metastatic Potential of Breast Cancer Cells is Indicated by Adhesion Strength.  P. Beri, A. Popravko1, A. Chiang1, J.K. Placone1, A. Banisadr2, A.J. Engler1,2; 1Bioengineering, UCSD, San Diego, CA, 2Biomedical Sciences, UCSD, San Diego, CA

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